People

Moving forward with a BS in biology I decided to focus on math and computational methods to address biological questions. After completing a MS in statistics and a PhD in bioinformatics in Greece I was involved in many projects in the fields of ESC reprogramming, differentiation, and cancer biology in the early stages of my postdoc. While numerous sequencing techniques and approaches were and are evolving in the field of molecular biology, 3D chromatin organization (the art in biology) caught my eye and decided to move into NYC and join Effie’s lab to work with experts in the 3D genome field. I am currently an instructor of molecular biology in Medicine trying to identify and uncover the properties of 3D enhancer and promoter networks (3D-HUBs) and the impact of HUB-rewiring in gene expression and 3D structure.

My research goal is to elucidate the epigenetic mechanisms regulating stemness
acquisition, maintenance and alterations in lymphoid malignancies. During my PhD
at the Gustave Roussy Cancer Center in Paris, I have developed several mouse
models to understand the oncogenic cooperation involving TET2 and DNMT3A
mutations, coexisting in T-cell lymphoma patients. I expanded my knowledge on the
function of these epigenetic drivers when I joined Effie’s lab in 2016 by studying
their role in the modulation of genomic imprinting at the Dlk1-Dio3 locus, crucial for
proper stemness acquisition and development potential in vivo. I am currently
interested in understanding the capacity of specific mature B-cells to manifest stem-
cell features as well as to how the latter can be hijacked upon specific mutations and
contribute to disease aggressiveness or relapse in lymphoma patients. I have
received postdoctoral fellowships from the Lady Tata Memorial Trust and the
Lymphoma Research Foundation (Oliver W. Press Memorial Postdoctoral Fellow). I
also integrated the Laboratory/Translational Track of LRF Lymphoma Scientific
Research Mentoring Program mentoring and supporting trainee’s transition from
fellow to faculty.
Email: [email protected] and Twitter @: LScourzic

I’m a NYSTEM post-doctoral fellow in the Apostolou lab. I have a B.S. from the University of Virginia and a M.S. from the College of William and Mary, where I studied how changes in cytoskeletal organization were controlled during C. elegans spermatogenesis. I did my doctoral studies at the UNC-Chapel Hill where I researched how ecdysone hormone signaling in D. melanogaster elicits different gene expression responses throughout the animal and over time. You can follow me on Twitter: @cmuyehara or visit my website: www.cmuyehara.com

I graduated from Seoul National University in 2020 spring with a B.S. in Biological Sciences and Computer Science & Engineering. After joining the BCMB PhD program at WCGS in 2020 fall, I got into the field of chromatin architecture and started working on elucidating the regulatory mechanism of cell identity using diverse approaches.

I obtained my Bachelor in Biotechnology at the University of Salamanca and my Master in Nanobiophysics at the Technical University of Dresden. Back then I started to get interested in the microtubule cytoskeleton and its role in mitosis. I was awarded a Marie Skłodowska–Curie fellowship to do my PhD at the Center for Genomic Regulation (CRG) in Barcelona as part of a multidisciplinary training network focused on cell division. Within my project I used in vitro reconstitution assays, a variety of microscopy techniques and cell culture to investigate the role of a chromatin modifier complex on the regulation of microtubule dynamics during mitosis. The dual-role of this chromatin modifier both in the chromatin of interphase cells and in the microtubules of dividing cells caught my attention and for my future steps I decided to gain more insights on the chromatin structure and regulation during mitosis. Thus, I recently joined the Apostolou lab as a postdoctoral researcher to study how mitotic bookmarking and chromatin architecture  in mitosis determine cell-fate decisions in stem cells.

After graduating with a degree in Biology from Columbia University, I decided to pursue a medical degree at Temple University. During medical school, I worked in a lab studying mitochondrial calcium signaling and specifically the mitochondrial calcium uniporter (MCU)’s structure, regulation and role in cellular metabolism. After medical school, I decided to pursue a career in surgery, and I am a surgery resident at Weill Cornell- New York Presbyterian Hospital. During my research years during surgery residency, I became interested in studying cancer epigenetics using high-throughput sequencing techniques with integrative computational analysis and decided to join the Physiology, Biophysics and Systems Biology PhD program here at Weill Cornell. Now, as a graduate student in the Apostolou lab, my work focuses on studying the role of 3D chromatin architecture in mechanisms that drive oncogenic programs in glioblastoma.

As a postdoctoral researcher in the Apostolou Lab, I am broadly interested in understanding the relationship between 3D genome architecture and gene regulation. My research aims to elucidate the functional significance and mechanism of formation of architectural stripes and enhancer hubs.  I am using chromosome conformation capture data from assays such as HiC, HiChIP and Micro-C to identify and study these architectural features.  I hold a PhD in Genomics and Systems Biology from New York University where my doctoral research investigated the role of nuclear actin in regulating 3D genome architecture and enhancer promoter interactions. Before joining NYU, I completed my MS in Cell and Molecular Biology as a Fulbright Scholar at the University of Arkansas.

As an undergraduate, I studied Medical Biotechnology at the University of Naples Federico II. After a year abroad as a pre-doctoral trainee at the University College Dublin and the Weizmann Institute of Science, I moved to Milan where I obtained a Ph.D. in Molecular Medicine at Vita-Salute San Raffaele University. While there, I worked on hypoxia pathway in the contest of acute myeloid leukemia (AML), and found a new function of the hypoxia responsive transcription factor HIF2a in blocking leukemic blasts differentiation. I joined Weill Cornell Medicine in 2023, and I am currently working as a co-mentored postdoc in Apostolou and Melnick labs. My research interest focuses on studying 3D chromatin organization and 3D hubs in germinal center B (GCB) cells and Diffuse large B cell lymphoma (DLBCL). I will focus on a specific locus control region (LCR) present in GCB and lymphoma cells to define its role in during germinal center reaction and lymphomagenesis.

After earning my degree in Computer Science and Molecular, Cellular & Developmental Biology from the University of Colorado Boulder, I participated in the postbaccalaureate program at the NIH, where I conducted research on GWAS variants in Pancreatic Cancer. I then enrolled in the Tri-I Computational Biology and Medicine PhD program where I currently work in the labs of Effie Apostolou and Christina Leslie. My research is centered on the computational analysis and prediction of 3D chromatin architecture and its impact on gene expression, especially in the context of cancer.